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Ascension is inspired by the real-life Project Orion that existed under the administration of President John F. Kennedy.[3] The show sets up an alternate version of reality beginning in 1963, when President Kennedy and the U.S. government, fearing the Cold War will become hot and lead to the destruction of Earth, decide to launch a covert space mission. They send 350 volunteers, including men, women and children, into space on a century-long voyage aboard the USS Ascension, a massive, self-sustaining generation ship. Their mission is to colonize a planet orbiting Proxima Centauri,[4] assuring the survival of the human race. At 51 years into the journey (i.e. in the present), as they approach the point of no return, the mysterious murder of a young woman – the first homicide since their departure[5] – causes the ship's crew to question the true nature of their mission.